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AT7867
Cat. No.:
0225LY-0810
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, HPLC, and LC-MS.
Size:
Add to basket
Product Overview
Description:
AT7867 is a powerful ATP-competitive inhibitor of p70S6K/PKA and Akt1/2/3, with IC50 values ranging from 17 nM to 85 nM, while remaining largely inactive against kinases outside the AGC family.
Synonym:
857531-00-1; 4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine; 4-(4-(1H-pyrazol-4-yl)phenyl)-4-(4-chlorophenyl)piperidine; Piperidine, 4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]-; Pyrazole-based inhibitor 9; 4-(4-Chloro-phenyl)-4-[4(1H-pyrazol-4-yl)-phenyl]-piperidine
CAS No.:
857531-00-1
Compound CID:
11175137
Formula:
C20H20ClN3
Formula Weight:
337.85
Specification
Targets&IC50:
Akt3: 47 nM; PKA: 20 nM; p70 S6K: 85 nM; Akt1: 32 nM; Akt2: 17 nM
Relative Density:
1.214 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
AT7867 can be used in drug discovery research to study the potent inhibition of AKT and p70S6K in cancer cells.
Library Information
Target:
PKA; Akt; S6 Kinase
Receptor:
Akt1; Akt2; Akt3; p70 S6K; PKA; RSK
Pathways:
Cytoskeletal signaling; Tyrosine kinase/adaptors; PI3K/Akt/mTOR signaling; MAPK
Plate Number:
AOCL-11
Plate Location:
d9
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
63 mg/mL; 186.47 mM
Water Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
Ethanol Max Solubility:
5 mg/mL; 14.8 mM
ALogP:
3.85
HBA_Count:
1
HBD_Count:
2
Rotatable Bond:
3
