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GSK180736A
Cat. No.:
0225LY-1345
Appearance:
Solid
Purity:
≥98%
Identity:
Confirmed by NMR, and LC-MS.
Size:
Add to basket
Product Overview
Description:
GSK180736A is a selective GRK2 inhibitor (IC50: 0.77 uM) that also effectively inhibits ROCK1 (IC50: 100 nM) while showing minimal activity against PKA.
Synonym:
GSK180736; 817194-38-0; 4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide; 4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide; 4-(4-fluorophenyl)-N-(2H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS No.:
817194-38-0
Compound CID:
11233873
Formula:
C19H16FN5O2
Formula Weight:
365.36
Specification
Targets&IC50:
GRK2: 0.77 μM; ROCK1: 100 nM
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
GSK180736A can be used in kinase research to investigate the selective inhibition of Rho-associated protein kinase (ROCK1).
Library Information
Target:
GRK; PKA; ROCK
Receptor:
GRK1; GRK2; GRK5; PKA; ROCK
Pathways:
Cytoskeletal signaling; GPCR/G protein signaling; Cell cycle/Checkpoint; Tyrosine kinase/adaptors; Stem cell regulation
Plate Number:
AOCL-18
Plate Location:
c3
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
100 mg/mL; 273.7 mM
Water Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
Ethanol Max Solubility:
3 mg/mL; 8.21 mM
