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Oridonin
Cat. No.:
0225LY-1312
Purity:
≥99%
Identity:
Confirmed by NMR, and LC-MS.
Size:
Add to basket
Product Overview
Description:
Oridonin is a diterpenoid derived from Rabdosia rubescens that provides anti-inflammatory, anti-bacterial, and anti-tumor effects by acting as an inhibitor of AKT1 and AKT2 (IC50: 8.4 and 8.9 uM, respectively).
Synonym:
NSC-250682; Rubescenin; Isodonol; Rubescensin A; 28957-04-2; lasidonin; (14R)-7-alpha,20-Epoxy-1-alpha,6-beta,7,14-tetrahydroxykaur-16-en-15-one; (1-alpha,6-beta,7-alpha,14R)-7,20-Epoxy-1,6,7,14-tetrahydroxykaur-16-en-15-one; Kaur-16-en-15-one, 7,20-epoxy-1,6,7,14-tetrahydroxy-, (1alpha,6beta,7alpha,14R)-; (1alpha,6beta,7alpha,14R)-7,20-epoxy-1,6,7,14-tetrahydroxykaur-16-en-15-one
CAS No.:
28957-04-2
Compound CID:
5321010
Formula:
C20H28O6
Formula Weight:
364.44
Specification
Targets&IC50:
Akt2: 8.9 μM; Akt1: 8.4μM
Relative Density:
1.42 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Oridonin can be used in cancer biology to investigate the induction of cell cycle arrest and autophagy in various tumor cell lines.
Library Information
Target:
Akt
Receptor:
Akt1; Akt2
Pathways:
Cytoskeletal signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling
Plate Number:
AOCL-17
Plate Location:
g9
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
65 mg/mL; 178.36 mM
Water Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
Ethanol Max Solubility:
28 mg/mL; 76.83 mM
