Products
Online Inquiry
DSPE-PEG2000-TCO (axial)
Cat. No.:
OB0626WX-3594
Appearance:
Solid
Purity:
≥95%
Identity:
Confirmed by NMR and HPLC.
Size:
Add to basket
Product Overview
Description:
DSPE-PEG2000-TCO (axial) is a conformationally optimized, highly reactive PEGylated phospholipid derivative wherein the trans-cyclooctene moiety is locked in a high-energy axial conformation. This precise stereochemical configuration significantly increases the kinetics of bioorthogonal click chemistry reactions, making it an advanced molecular anchor for executing rapid, highly efficient surface ligation onto lipid nanoparticle matrices.
Conjugation:
TCO-functionalized
Synonyms:
(2R)-3-((((1-(((R,E)-cyclooct-4-en-1-yl)oxy)-1,9-dioxo-5,8-dioxa-2,10-diazadodecan-12-yl)oxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl distearate; 1,2-Distearoyl-sn-glycero-3-PE-Polyethylene Glycol-2000-trans-cyclooctene (axial); 1,2-Distearoyl-sn-glycero-3-Phosphoethanolamine-Polyethylene Glycol-2000-trans-cyclooctene (axial)
Formula:
(C2H4O)nC53H99N2O12P
Specification
Source:
Synthetic
Solubility in DMSO:
≥10 mg/mL
Solubility in Ethanol:
0.1-1 mg/mL
Storage:
Storage at -20°C.
Applications:
DSPE-PEG2000-TCO (axial) is used as a bioorthogonally functionalized phospholipid reagent for nanoparticle engineering and conjugation studies. It supports the preparation of chemically modified lipid assemblies, surface functionalization, and investigation of targeted delivery strategies.