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C14-4
Cat. No.:
OB0626WX-3868
Appearance:
Liquid
Purity:
≥95% (mixture of isomers)
Identity:
Confirmed by NMR and TLC.
Size:
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Product Overview
Description:
C14-4 is a pH-responsive ionizable cationic lipid with a pKa of 6.5, engineered as a high-performance vector for cellular engineering and tissue-directed transcript delivery. This lipid matrix mediates efficient ex vivo transcript translation in primary immune cells with minimal cellular toxicity, and its bio-distribution profiles can be modulated via auxiliary lipid combinations to selectively direct payload accumulation to uterine, pulmonary, or intestinal tissue zones.
Synonyms:
1,1′-[[2-[2-[4-[2-[2-[2-[bis(2-hydroxytetradecyl)amino]ethoxy]ethylamino]ethyl]-1-piperazinyl]ethoxy]ethyl]imino]bis-2-tetradecanol; C14-494 Lipid B4; 2639634-80-1; 1,1'-((2-(2-(4-(2-((2-(2-(Bis(2-hydroxytetradecyl)amino)ethoxy)ethyl)(2-hydroxytetradecyl)amino)ethyl)piperazin-1-yl)ethoxy)ethyl)azanediyl)bis(tetradecan-2-ol); 1-[2-[2-[bis(2-hydroxytetradecyl)amino]ethoxy]ethyl-[2-[4-[2-[2-[bis(2-hydroxytetradecyl)amino]ethoxy]ethyl]piperazin-1-yl]ethyl]amino]tetradecan-2-ol
CAS No.:
2639634-80-1
Compound CID:
164687424
Formula:
C84H173N5O7
Formula Weight:
1365.3
Specification
Solubility in Ethanol:
10 mg/mL
Storage:
Storage at -20°C.
Applications:
C14-4 serves as a synthetic lipid for developing lipid nanoparticle delivery systems. It supports comparative formulation studies, optimization of lipid compositions, nucleic acid delivery research, and characterization of nanoparticle properties.
