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244cis
Cat. No.:
OB0626WX-3828
Appearance:
Liquid
Purity:
≥95%
Identity:
Confirmed by NMR, TLC, and HPLC.
Size:
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Product Overview
Description:
244cis is an unsaturated ionizable cationic lipid characterized by an apparent pKa of 6.3, engineered as a high-performance core matrix for responsive lipid nanoparticles. This cis-double-bond-containing framework directs transcript expression toward pulmonary architectures—including endothelial, epithelial, immune, and fibroblastic networks—while minimizing systemic chemokine spikes; additionally, when delivering silencing payloads, it drives superior mitigation of hepatic fibrosis and restricts pro-inflammatory cytokine cascades compared to traditional benchmark ionizable structures.
Synonyms:
4-[2-[bis[9-[(2Z)-2-nonen-1-yloxy]-9-oxononyl]amino]ethyl]-1-piperazinenonanoic acid, (2Z)-2-nonen-1-yl ester; P13-8Y; 244-9-cis; [(Z)-non-2-enyl] 9-[4-[2-[bis[9-[(Z)-non-2-enoxy]-9-oxononyl]amino]ethyl]piperazin-1-yl]nonanoate; 2956402-64-3
CAS No.:
2956402-64-3
Compound CID:
171038201
Formula:
C60H111N3O6
Formula Weight:
970.6
Specification
Solubility in Ethanol:
25 mg/mL
Storage:
Storage at -20°C.
Applications:
244cis serves as an experimental ionizable lipid for developing lipid nanoparticle formulations. It supports optimization of nucleic acid delivery systems, formulation screening, structure–activity relationship investigations, and characterization of lipid nanoparticle physicochemical properties.