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DMPAC-Chol
Cat. No.:
OB0626WX-3971
Appearance:
Crystalline solid
Purity:
≥95%
Identity:
Confirmed by IR and TLC.
Size:
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Product Overview
Description:
DMPAC-Chol is a cationic cholesterol derivative engineered to function as an electrostatic vector for non-viral gene delivery. This amphiphilic molecule binds plasmid DNA to form protective complexes that resist serum nuclease degradation, while demonstrating concentration-dependent membrane-disrupting capabilities that modulate cellular viability profiles.
Synonyms:
(3β)-cholest-5-en-3-ol 3-[[3-(dimethylamino)propyl]carbamate]; Chol-T; 184582-91-0; [(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] N-[3-(dimethylamino)propyl]carbamate; Cholesterol 3-dimethylaminopropylcarbamate; Chol-T, DMPAC-Chol; (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl (3-(dimethylamino)propyl)carbamate; (3beta)-cholest-5-en-3-ol 3-[[3-(dimethylamino)propyl]carbamate]
CAS No.:
184582-91-0
Compound CID:
12021232
Formula:
C33H58N2O2
Formula Weight:
514.8
Specification
Solubility in Ethanol:
10 mg/mL
Solubility in DMF:
10 mg/mL
Solubility in Other Solvents:
Ethanol:PBS mixture: 0.14 mg/mL
Storage:
Storage at -20°C.
Applications:
DMPAC-Chol serves as a cholesterol-based cationic lipid for the construction and optimization of lipid delivery systems. It supports studies of lipid nanoparticle formulation, nucleic acid encapsulation strategies, and structure–property relationships of synthetic lipid carriers.