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Cho-Arg, trifluoroacetate salt
Cat. No.:
OB0626WX-3980
Appearance:
Liquid
Purity:
≥95%
Identity:
Confirmed by NMR, TLC, and IR.
Size:
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Product Overview
Description:
Cho-Arg is a steroid-based cationic lipid composed of a lipophilic cholesterol core linked to an L-arginine headgroup, engineered for non-viral gene transfection. This compound binds plasmid DNA to form stable complexes that restrict electrophoretic migration, initiating intracellular cargo transport via specialized lipid-raft and caveolae-mediated endocytosis in both serum-supplemented and serum-free environments.
Synonyms:
Cholest-5-en-3-ol (3β)-3-[6-[[(2S)-2-amino-5-[(aminoiminomethyl)amino]-1-oxopentyl]amino]hexanoate], 2,2,2-trifluoroacetate (1:2); 1609010-56-1; cholest-5-en-3-ol(3beta)-3-[6-[[(2S)-2-amino-5-[(aminoiminomethyl)amino]-1-oxopentyl]amino]hexanoate],2,2,2-trifluoroacetate(1:2); [(4S)-4-azaniumyl-5-[[6-[[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-oxohexyl]amino]-5-oxopentyl]-(diaminomethylidene)azanium;2,2,2-trifluoroacetate
CAS No.:
1609010-56-1
Compound CID:
137700519
Formula:
C39H71N5O3 • 2CF3COO
Formula Weight:
884.1
Specification
Solubility in DMSO:
50 mg/mL
Solubility in Ethanol:
50 mg/mL
Solubility in DMF:
50 mg/mL
Solubility in Other Solvents:
Ethanol:PBS mixture: 0.25 mg/mL
Storage:
Storage at -20°C.
Applications:
Cho-Arg, trifluoroacetate salt serves as a cholesterol-based conjugate for studies of lipid carrier design and membrane-associated delivery systems. It supports investigation of lipid–cargo interactions, formulation optimization, and characterization of synthetic cholesterol derivatives.