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Chlorotoxin, trifluoroacetate salt
Cat. No.:
OB0626WX-3706
Appearance:
Solid
Purity:
≥95%
Identity:
Confirmed by NMR and HPLC.
Size:
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Product Overview
Description:
Chlorotoxin is a highly specialized peptide scaffold containing a structured network of disulfide bridges that dictate its unique binding conformation. In cell-free screening assays, this peptide selectively binds to matrix metalloproteinase-2 and neuropilin-1 without blocking their native enzymatic pathways, while also modulating specific chloride currents across isolated plasma membranes. While maintaining a non-cytotoxic profile toward various epithelial and glioma cell networks, it functions as an exceptional targeting domain when integrated into chimeric antigen receptors or liposomal surfaces, directing therapeutic delivery vehicles to cross biological barriers, reduce tumor mass, and maximize survival in glioblastoma models.
Synonyms:
L-methionyl-L-cysteinyl-L-methionyl-L-prolyl-L-cysteinyl-L-phenylalanyl-L-threonyl-L-threonyl-L-α-aspartyl-L-histidyl-L-glutaminyl-L-methionyl-L-alanyl-L-arginyl-L-lysyl-L-cysteinyl-L-α-aspartyl-L-α-aspartyl-L-cysteinyl-L-cysteinylglycylglycyl-L-lysylglycyl-L-arginylglycyl-L-lysyl-L-cysteinyl-L-tyrosylglycyl-L-prolyl-L-glutaminyl-L-cysteinyl-L-leucyl-L-cysteinyl-L-argininamide, cyclic (2→19),(5→28),(16→33),(20→35)-tetrakis(disulfide), trifluoroacetate salt; CTX; TM-601
Formula:
C158H249N53O47S11 • XCF3COOH
Formula Weight:
3995.7
Specification
Solubility in Other Solvents:
Water: 1-10 mg/mL
Storage:
Storage at -20°C.
Applications:
Chlorotoxin, trifluoroacetate salt serves as a targeting peptide reagent for chemical biology and delivery research. It supports studies involving peptide-functionalized systems, ligand-mediated recognition strategies, and the development of targeted biomaterial platforms.