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CBL0137 HCl
Cat. No.:
OB0225WX-2757
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
Add to basket
Product Overview
Description:
CBL0137 (Curaxin 137) HCl is a dual-action molecule that activates p53 and inhibits NF-kB (EC50: 0.37 microM and 0.47 microM, respectively) while also targeting the histone chaperone FACT complex.
Synonym:
Curaxin 137 HCl; 1197397-89-9; CBL0137 hydrochloride; cblc137 hydrochloride; 1-[6-acetyl-9-[2-(propan-2-ylamino)ethyl]carbazol-3-yl]ethanone;hydrochloride; 1,1'-(9-(2-((1-Methylethyl)imino)ethyl)-9H-carbazole-3,6-diyl)bisethanone, hydrochloride (1:1); 1,1'-(9-(2-(Isopropylamino)ethyl)-9H-carbazole-3,6-diyl)diethanone hydrochloride; CBL-C137 hydrochloride; Curaxin-137 hydrochloride; CBL0137 (hydrochloride); 3,6-Diacetyl-9-(2-isopropylamino-ethyl)-9H-carbazole Hydrochloride; 1,1'-(9-(2-(Isopropylamino)ethyl)-9H-carbazole-3,6-diyl)bis(ethan-1-one) hydrochloride
CAS No.:
1197397-89-9
Compound CID:
44519123
Formula:
C21H24N2O2·HCl
Formula Weight:
372.89
Specification
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
CBL0137 HCl is utilized in oncology and molecular biology as a small molecule curaxin to investigate the stabilization of the FACT complex and the activation of p53-mediated stress responses.
Library Information
Target:
NF-κB; p53
Receptor:
NF-κB; p53
Pathways:
Apoptosis
Plate Number:
L6700-10
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
38 mg/mL; 101.91 mM
Water Max Solubility:
24 mg/mL; 64.36 mM
ALogP:
3.72
HBA_Count:
2
HBD_Count:
1
Rotatable Bond:
6
