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GSK481
Cat. No.:
OB0225WX-2730
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
GSK481 functions as a specific inhibitor of Receptor Interacting protein kinase 1 (RIP1/RIPK1), a mechanism recognized for its ability to obstruct necrotic cell death.
Synonym:
1622849-58-4; GSK'481; GSK-481; (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)isoxazole-3-carboxamide; 5-Benzyl-N-[(3s)-5-Methyl-4-Oxo-2,3,4,5-Tetrahydro-1,5-Benzoxazepin-3-Yl]-1,2-Oxazole-3-Carboxamide; 5-benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1,2-oxazole-3-carboxamide
CAS No.:
1622849-58-4
Compound CID:
90351311
Formula:
C21H19N3O4
Formula Weight:
377.39
Specification
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
GSK481 is used in biochemical research as a highly potent and selective RIPK1 inhibitor to investigate the specific contribution of RIPK1 kinase activity to inflammatory signaling and cell death.
Library Information
Target:
RIP kinase
Receptor:
RIPK1
Pathways:
Apoptosis
Plate Number:
L6700-10
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
75 mg/mL; 198.73 mM
ALogP:
2.545
HBA_Count:
5
HBD_Count:
1
Rotatable Bond:
4
