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AEM1
Cat. No.:
0225LY-1435
Appearance:
Solid
Purity:
≥97%
Identity:
Confirmed by NMR, and LC-MS.
Size:
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Product Overview
Description:
AEM1 is a compound that targets deregulated NRF2 activity in cancer, effectively sensitizing A549 cells to chemotherapy and hindering tumor growth both in vitvo and in vitro.
Synonym:
1030123-90-0; N-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine; 1-(2H-1,3-benzodioxol-5-yl)-N-[5-(4-fluorophenyl)-1H,4H-thieno[2,3-d]pyrimidin-4-ylidene]methanamine; N-(1,3-Benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)-thieno[2,3-d]pyrimidin-4-amine; N-(1,3-benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine; N-(1,3-benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)-thieno[2,3-d]pyrimidine-4-amine; N-(Benzo[d][1,3]dioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4(1H)-imine; 1-(1,3-dioxaindan-5-yl)-N-[5-(4-fluorophenyl)-1H,4H-thieno[2,3-d]pyrimidin-4-ylidene]methanamine
CAS No.:
1030123-90-0
Compound CID:
9196193
Formula:
C20H14FN3O2S
Formula Weight:
379.41
Specification
Relative Density:
1.457 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
AEM1 can be used in cell biology to explore the inhibition of specific transcription factor pathways involved in metabolic regulation.
Library Information
Target:
Nrf2
Receptor:
Transcription factor
Pathways:
Oxidative stress; Immunology/Inflammation; Chromatin/Epigenetic
Plate Number:
AOCL-19
Plate Location:
d8
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
30 mg/mL; 79.07 mM
