Product Overview
Description:
AdipoUpX™ Human NPY MSCV Particle (Overexpression) is a high-titer MSCV particle designed for the specific and efficient stable overexpression of the human NPY gene. Neuropeptide Y is one of the most potent orexigenic signals in the hypothalamus, stimulating food intake and promoting fat storage. This system is optimized for stem cells, hematopoietic stem cells, etc., ensuring robust expression for investigating hunger-signaling mechanisms. The viral system features a modular design, and all batches pass through comprehensive quality control to ensure experimental safety and reproducibility.
Production Cell Line:
HEK293T
Promoter:
Ubi; CMV; EF1a; Others
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Final QC confirmed the correct molecular size and integrity of the insert through specific PCR amplification.
Sterility Test:
No microbial contamination was detected in any product.
Mycoplasma Test:
No mycoplasma presence was detected in this final viral preparation upon comprehensive testing.
Other QC:
Our service scope includes both customized supplementary testing and comprehensive in vitro/in vivo transduction assessments.
Storage:
The necessity of immediate transfer to -80 °C storage following receipt is crucial for upholding the product's integrity.
Stability:
Biological activity remains intact for 6-12 months when stored at -80°C. Once removed from the freezer, the diluted working material is stable for up to 2-3 weeks at 4°C.
Shipping Condition:
Our MSCV retroviral products are shipped using dry ice.
Handling Notes:
Store the vector according to specified conditions and aliquot it immediately upon receipt into low-protein-binding tubes, which is necessary to maintain titer because viral particles are highly sensitive to both temperature fluctuations and freeze-thaw cycles.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Throughout all operational processes, users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements. Although our company commits to product quality via rigorous internal QC inspections, the complexity of experimental conditions means we cannot guarantee product performance or experimental results in any specific application.
Target Profile
Gene Name:
NPY
Full Name:
Neuropeptide Y
Gene Symbol:
PYY4
Summary:
NPY encodes one of the most abundant and potent neuropeptides in the central nervous system. It acts through various G protein-coupled receptors to stimulate food intake, decrease energy expenditure, and regulate the stress response. As a powerful orexigenic (appetite-stimulating) agent, NPY is a central player in the development of obesity. A specific genetic polymorphism in its signal peptide (leading to a leucine-to-proline change) has been associated with higher cholesterol levels, increased body mass index (BMI), and an elevated risk for metabolic and cardiovascular diseases.
