AdipoUpX™ Human LEPR Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human LEPR Lentiviral Particle (Overexpression) is professionally engineered for the long-lasting, stable overexpression of the human LEPR gene. LEPR is the key entry point for LEP signaling. This stable integration tool allows systematic investigation into leptin resistance and downstream JAK/STAT activation. It serves as a powerful tool for in vitro functional validation and signaling studies. The product is ready-to-use, high-titer, and all particles undergo comprehensive quality control.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: LEPR

Full Name: Leptin receptor

Gene Symbol: OBR; OB-R; CD295; LEP-R; LEPRD

Gene ID: 3953

RefSeq ID: NM_001003679.3, NP_001003679.1

Summary: The protein encoded by the LEPR gene is a key member of the cytokine receptor 130 family, serving as the primary docking site for leptin (a body fat-regulating hormone). This receptor serves as a central hub linking fat storage and the central nervous system to regulate body fat metabolism by activating signaling pathways such as cytoplasmic STAT proteins. Functional mutations in LEPR are not only associated with human obesity but can also cause pituitary dysfunction. Notably, the LEPR gene shares its promoter and first two exons with its regulatory partner LEPROT, reflecting a complex and precise gene regulatory network.

AdipoUpX™ Human LEPR Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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