Product Overview
Description:
AdipoUpX™ Human B2M MSCV Particle (Overexpression) is a high-titer retroviral tool engineered for stable overexpression of the human B2M gene. B2M is a component of MHC class I complexes and is associated with immune-metabolic interactions relevant to obesity-related inflammation. The MSCV backbone ensures durable expression in hematopoietic stem cells, stem cells, and other mammalian systems. All preparations are QC-verified to ensure consistency, safety, and reproducibility.
Production Cell Line:
HEK293T
Promoter:
Ubi; CMV; EF1a; Others
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Final QC confirmed the correct molecular size and integrity of the insert through specific PCR amplification.
Sterility Test:
No microbial contamination was detected in any product.
Mycoplasma Test:
No mycoplasma presence was detected in this final viral preparation upon comprehensive testing.
Other QC:
Our service scope includes both customized supplementary testing and comprehensive in vitro/in vivo transduction assessments.
Storage:
The necessity of immediate transfer to -80 °C storage following receipt is crucial for upholding the product's integrity.
Stability:
Biological activity remains intact for 6-12 months when stored at -80°C. Once removed from the freezer, the diluted working material is stable for up to 2-3 weeks at 4°C.
Shipping Condition:
Our MSCV retroviral products are shipped using dry ice.
Handling Notes:
Store the vector according to specified conditions and aliquot it immediately upon receipt into low-protein-binding tubes, which is necessary to maintain titer because viral particles are highly sensitive to both temperature fluctuations and freeze-thaw cycles.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Throughout all operational processes, users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements. Although our company commits to product quality via rigorous internal QC inspections, the complexity of experimental conditions means we cannot guarantee product performance or experimental results in any specific application.
Target Profile
Gene Name:
B2M
Full Name:
Beta-2-microglobulin
Gene Symbol:
IMD43; AMYLD6; MHC1D4
Summary:
B2M produces a small serum protein that associates with MHC class I heavy chains on the surface of most nucleated cells. Structurally rich in beta-sheets, the protein can form amyloid aggregates under pathological conditions. It also exhibits antimicrobial properties, including activity in amniotic fluid. Disruption of this gene has been associated with abnormal protein catabolism and hypoproteinemia.
