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Zileuton
Cat. No.:
OB0225WX-1597
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and LC-MS.
Size:
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Product Overview
Description:
Zileuton is a synthetic hydroxyurea derivative that prevents the conversion of arachidonic acid into leukotrienes by selectively blocking the 5-lipoxygenase enzyme.
Synonym:
Abbott 64077; A 64077; 111406-87-2; Zyflo; Leutrol; 1-(1-(Benzo[b]thiophen-2-yl)ethyl)-1-hydroxyurea; Zyflo CR; Zileutonum; 1-[1-(1-benzothiophen-2-yl)ethyl]-1-hydroxyurea; A-64077; N-(1-Benzo(b)thien-2-ylethyl)-N-hydroxyurea; ABBOTT-64077; A 64077; Zyflo (TN); Urea, N-(1-benzo[b]thien-2-ylethyl)-N-hydroxy-; MFCD00866097; (+-)-1-(1-Benzo(b)thien-2-ylethyl)-1-hydroxyurea; 1-[1-(1-benzothien-2-yl)ethyl]-1-hydroxyurea; N-[1-(benzo[b]thiophen-2-yl)ethyl]-N-hydroxyurea; (+/-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea; (+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea; Urea, N-(1-benzo(b)thien-2-ylethyl)-N-hydroxy-; (+/-)-1-(1-benzo(b)thien-2-ylethyl)-1-hydroxyurea; 1-(1-(1-benzothien-2-yl)ethyl)-1-hydroxyurea; N-(1-(benzo(b)thiophen-2-yl)ethyl)-N-hydroxyurea
CAS No.:
111406-87-2
Compound CID:
60490
Formula:
C11H12N2O2S
Formula Weight:
236.29
Specification
Relative Density:
1.401 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Zileuton is applied in respiratory research as an orally active 5-lipoxygenase inhibitor to study the blockage of leukotriene formation and its impact on airway inflammation.
Library Information
Target:
Lipoxygenase; COX
Receptor:
5-Lipoxygenase; COX-1
Pathways:
Apoptosis; Neuronal signaling; Metabolism; Immunology/Inflammation
Plate Number:
AOCL-21
Plate Location:
e2
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
75 mg/mL; 317.41 mM
ALogP:
2.184
HBA_Count:
1
HBD_Count:
1
Rotatable Bond:
2





