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SKI V
Cat. No.:
0225LY-1144
Appearance:
Solid
Purity:
≥98%
Identity:
Confirmed by NMR, and LC-MS.
Size:
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Product Overview
Description:
SKI V acts as a non-lipid inhibitor of both sphingosine kinase (IC50: 2 μM) and PI3K (IC50: 6 μM), demonstrating antitumor activity by inducing apoptosis.
Synonym:
24418-86-8; (2Z)-2-[(3,4-dihydroxyphenyl)methylidene]-1-benzofuran-3-one; 2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one, Sphingosine kinase inhibitor V; (Z)-2-(3,4-Dihydroxybenzylidene)benzofuran-3(2H)-one; SKiv; 3',4'-dihydroxyaurone; SKI V?; 2-[(Z)-3,4-Dihydroxybenzylidene]-2,3-dihydrobenzofuran-3-one
CAS No.:
24418-86-8
Compound CID:
5793932
Formula:
C15H10O4
Formula Weight:
254.24
Specification
Targets&IC50:
GST-hSK: 2 μM ; PI3k (human): 6 μM ; ERK2: 80 μM
Relative Density:
1.489 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
SKI V can be used in lipid research to study the inhibition of sphingosine kinase 1.
Library Information
Target:
PI3K; S1P receptor
Receptor:
PI3K; S1P
Pathways:
Apoptosis; PI3K/Akt/mTOR signaling; GPCR/G protein signaling
Plate Number:
AOCL-15
Plate Location:
f10
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
2.55 mg/mL; 10.03 mM
