SIRT3 Blocking Peptide (C-RASGIPASKLVEAH)

Cat. No.: OB0526-WX10

Origin: Synthetic

Conjugation: Unconjugate

Species Reactivity: Human; Mouse; Rat; Porcine

Size:

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Product Overview

Description: SIRT3 Blocking Peptide (C-RASGIPASKLVEAH) is a sequence-defined synthetic peptide mimicking a unique structural epitope of mitochondrial sirtuin-3. It is specifically formulated to neutralize compatible SIRT3 antibodies, offering a vital control for verifying target specificity in mitochondrial metabolism and aging research.

Sequence: C-RASGIPASKLVEAH

Molecular Weight: 1596.8 Da

Purity: ≥95%

Applications: Western blotting; ELISA; IHC; IF; Functional Assay; Cell Culture; Binding Assay

Specification

Storage: Storage at -20°C.

Shipping Condition: Shipped with ice packs.

Handling Notes: During shipping, trace amounts of the blocking peptide may adhere to the interior surface of the vial cap. Before opening, it is highly recommended to briefly centrifuge the vial to bring all contents to the bottom.

Target Profile

Full Name: NAD-dependent protein deacetylase sirtuin-3, mitochondrial

Alternative Names: SIRT3; NAD-dependent protein delactylase sirtuin-3; Regulatory protein SIR2 homolog 3; SIR2-like protein 3; SIR2L3

Summary: Belonging to the sirtuin family of class III histone deacetylases (yeast Sir2 homologs), SIRT3 is a primary mitochondrial fidelity protein. It functions exclusively in mitochondria to mitigate oxidative stress by eliminating reactive oxygen species, inhibiting apoptosis, and suppressing tumor formation. Due to its central role in metabolic reprogramming, SIRT3 has broad implications in aging, neuroprotection, cardiovascular wellness, and nuclear gene regulation.

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