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SH2B1 Blocking Peptide (PFGASDCVTDHLP)
Cat. No.:
OB0526-WX4
Origin:
Synthetic
Conjugation:
Unconjugate
Species Reactivity:
Human; Mouse; Rat; Dog; Porcine; Cow
Size:
Add to basket
Product Overview
Description:
SH2B1 Blocking Peptide (PFGASDCVTDHLP) is an antigen-specific control peptide developed to neutralize SH2B1 anti-serum or monoclonal antibodies. It acts as a reliable negative control in immunoassay development, supporting precise structural and functional studies of the leptin and insulin signaling adaptor protein SH2B1.
Sequence:
PFGASDCVTDHLP
Molecular Weight:
1401.5 Da
Purity:
≥95%
Applications:
Western blotting; ELISA; IHC; IF; Functional Assay; Cell Culture; Binding Assay
Specification
Storage:
Storage at -20°C.
Shipping Condition:
Shipped with ice packs.
Handling Notes:
During shipping, trace amounts of the blocking peptide may adhere to the interior surface of the vial cap. Before opening, it is highly recommended to briefly centrifuge the vial to bring all contents to the bottom.
Target Profile
Full Name:
SH2B adapter protein 1
Alternative Names:
Pro-rich, PH and SH2 domain-containing signaling mediator (PSM); SH2B1; SH2 domain-containing protein 1B; KIAA1299; SH2B; SH2-B; SH2-B homolog; SH2-B gamma signaling protein
Summary:
SH2B1 encodes an adaptor protein containing an SH2 domain and functions as a mediator in intracellular signaling pathways. The protein facilitates activation of multiple kinases and plays a role in cytokine- and growth factor–dependent signaling events. Through these activities, SH2B1 contributes to cellular growth, differentiation, and metabolic regulation. The gene produces multiple transcript variants via alternative splicing, supporting functional complexity in signaling networks relevant to obesity and metabolic disease.
