Products
Online Inquiry
SAR131675
Cat. No.:
OB0225WX-2524
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
Add to basket
Product Overview
Description:
SAR131675 is a VEGFR3-targeting small molecule with an IC50 of 23 nM, exhibiting approximately 50-fold higher selectivity for VEGFR3 over VEGFR1 and minimal cross-reactivity with Akt1 or CDKs.
Synonym:
1433953-83-3; (R)-2-amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide; SAR 131675; 2-Amino-1-ethyl-7-[(3R)-3-hydroxy-4-methoxy-3-methylbut-1-ynyl]-N-methyl-4-oxo-1,8-naphthyridine-3-carboxamide; SAR-131675; (3S,4AS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamidemethanesulf; 2-amino-1-ethyl-7-[(3R)-3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl]-N-methyl-4-oxo-1,8-naphthyridine-3-carboxamide
CAS No.:
1433953-83-3
Compound CID:
71295845
Formula:
C18H22N4O4
Formula Weight:
358.39
Specification
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
SAR131675 is employed in cardiovascular and oncology research as a selective VEGFR-3 inhibitor to investigate the mechanisms of lymphangiogenesis and the regulation of vascular inflammation.
Library Information
Target:
VEGFR
Receptor:
VEGFR3
Pathways:
Protein tyrosine kinase
Plate Number:
L6700-04
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
72 mg/mL; 200.89 mM
Ethanol Max Solubility:
4 mg/mL
ALogP:
0.769
HBA_Count:
4
HBD_Count:
2
Rotatable Bond:
6
