NVP-ADW742

Cat. No.: OB0225WX-2391

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, and HPLC.

Size:

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Product Overview

Description: NVP-ADW742 is an IGF-1R inhibitor (IC50: 0.17 microM) demonstrating over 16-fold selectivity compared to the insulin receptor (InsR) and minimal activity against other kinases like HER2 or PDGFR.

Synonym: GSK 552602A, ADW742; 475488-23-4; ADW-742; 5-(3-phenylmethoxyphenyl)-7-[3-(pyrrolidin-1-ylmethyl)cyclobutyl]pyrrolo[2,3-d]pyrimidin-4-amine; cis-NVP-ADW742; 5-(3-(Benzyloxy)phenyl)-7-((1r,3r)-3-(pyrrolidin-1-ylmethyl)-cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine; 5-(3-(benzyloxy)phenyl)-7-((1r,3r)-3-(pyrrolidin-1-ylmethyl)cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine; 5-(3-(Benzyloxy)phenyl)-7-(cis-3-(pyrrolidin-1-ylmethyl)cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine; 5-(3-Benzyloxyphenyl)-7-[trans-3-[(pyrrolidin-1-yl)methyl]cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine; 7H-Pyrrolo(2,3-d)pyrimidin-4-amine, 5-(3-(phenylmethoxy)phenyl)-7-(trans-3-(1-pyrrolidinylmethyl)cyclobutyl)-; 5-(3-(benzyloxy)phenyl)-7-(3-(pyrrolidin-1-ylmethyl)cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine; 5-(3-Benzyloxyphenyl)-7-[trans-3-[(pyrrolidin-1-yl)methyl]cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine/NVP-ADW742

CAS No.: 475488-23-4

Compound CID: 9825149

Formula: C₂₈H₃₁N₅

Formula Weight: 453.58

Specification

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: NVP-ADW742 is employed in molecular pharmacology as a potent and selective IGF-1R inhibitor to investigate the role of insulin-like growth factor signaling in tumor cell survival and transformation.