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SGI-7079
Cat. No.:
OB0225WX-2709
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
SGI-7079 acts as a novel and selective Axl inhibitor with an in vitro IC50 of 58 nM, functioning as a molecular tool to investigate mechanisms for overcoming EGFR inhibitor resistance.
Synonym:
1239875-86-5; 2-(3-(2-((3-Fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)acetonitrile; SGI7079; 2-[3-[2-[3-fluoro-4-(4-methylpiperazin-1-yl)anilino]-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]phenyl]acetonitrile; Benzeneacetonitrile, 3-[2-[[3-fluoro-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-; 2-[3-(2-{[3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]amino}-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]acetonitrile; 3-[2-[[3-Fluoro-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]benzeneacetonitrile
CAS No.:
1239875-86-5
Compound CID:
46870258
Formula:
C26H26FN7
Formula Weight:
455.53
Specification
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
SGI-7079 is utilized in advanced oncology research as a potent and selective inhibitor of the Axl kinase to study the disruption of growth factor-mediated survival signaling and the prevention of tumor metastasis.
Library Information
Target:
Axl
Receptor:
Axl
Pathways:
Protein tyrosine kinase
Plate Number:
L6700-09
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
91 mg/mL; 199.77 mM
ALogP:
5.286
HBA_Count:
2
HBD_Count:
2
Rotatable Bond:
5
