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Regorafenib
Cat. No.:
OB0225LY-0423
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by HPLC.
Size:
Product Overview
Description:
Regorafenib is a multi-targeted small molecule tyrosine kinase inhibitor that targets tumor angiogenesis and cell proliferation.
Synonym:
BAY 73-4506; Fluoro-Sorafenib; 755037-03-7; 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide; 4-[4-[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide; 2-Pyridinecarboxamide,4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-
CAS No.:
755037-03-7
Compound CID:
11167602
Formula:
C21H15ClF4N4O3
Formula Weight:
482.82
Specification
Relative Density:
1.491 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Regorafenib can be used in cancer research, especially playing an important role in the regulation of the tumor microenvironment and angiogenesis.
Library Information
Targets:
Kinases
Receptors:
c-Kit; PDGFR; Raf-1; c-RET; VEGFR1; VEGFR2
Pathways:
Tyrosine kinase/adaptors; MAPK; Autophagy; Angiogenesis; Apoptosis
Plate Number:
AOCL-6
Plate Location:
d9
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10 mM DMSO
DMSO Max Solubility:
60 mg/mL; 124.27 mM
Water Max Solubility:
<1 mg/mL
Ethanol Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
Solubility:
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 9 mg/mL (18.64 mM)
ALogP:
4.381
HBA_Count:
4
HBD_Count:
3
Rotatable Bond:
6
