Products
- Anti-Obesity Compound Library
- GPCR/G Protein-Targeted Compounds
- Immunology/Inflammation-Targeted Compounds
- JAK/STAT-Targeted Compounds
- MAPK-Targeted Compounds
- Membrane Transporter/Ion Channel-Targeted Compounds
- Metabolism-Targeted Compounds
- NF-κB-Targeted Compounds
- Microbiology/Virology-Targeted Compounds
- Neuronal Signaling-Targeted Compounds
- PI3K/Akt/mTOR-Targeted Compounds
- Oxidation-reduction-Targeted Compounds
- Proteases/Proteasome-Targeted Compounds
- Stem Cells/Wnt-Targeted Compounds
- Tyrosine Kinase/Adaptors-Targeted Compounds
- Ubiquitin-Targeted Compounds
Online Inquiry
Baricitinib
Cat. No.:
0225LY-1291
Purity:
≥99%
Identity:
Confirmed by NMR, HPLC, and LC-MS.
Size:
Add to basket
Product Overview
Description:
Baricitinib is an orally active JAK1 and JAK2 inhibitor (IC50: 5.9/5.7 nM) with significant anti-inflammatory, anti-tumor, and immunomodulatory potential.
Synonym:
INCB028050; LY3009104; 1187594-09-7; Olumiant; INCB 028050; INCB-028050; 2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile; 1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile; 2-(3-(4-(3H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile
CAS No.:
1187594-09-7
Compound CID:
44205240
Formula:
C16H17N7O2S
Formula Weight:
371.42
Specification
Targets&IC50:
JAK3: >400 nM; TYK2: 53 nM; JAK1: 5.9 nM; JAK2: 5.7 nM
Relative Density:
1.56 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Baricitinib can be used in immunology research to investigate the selective inhibition of JAK1 and JAK2 signaling.
Library Information
Target:
JAK; Chk; Tyrosine kinases
Receptor:
Chk2; JAK1; JAK2; JAK3; Tyk2
Pathways:
Tyrosine kinase/adaptors; Angiogenesis; JAK/STAT signaling; Cell cycle/Checkpoint; Chromatin/Epigenetic; Stem cell regulation
Plate Number:
AOCL-17
Plate Location:
e8
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
250 mg/mL; 673.09 mM
Water Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
Ethanol Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
ALogP:
0.36
HBA_Count:
5
HBD_Count:
1
Rotatable Bond:
5
