Linsitinib (OSI-906)

Cat. No.: OB0225WX-2392

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, and HPLC.

Size:

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Product Overview

Description: Linsitinib (OSI-906) is a selective inhibitor of the IGF-1 receptor (IC50: 35 nM) that also displays modest inhibitory activity against the insulin receptor (IC50: 75 nM).

Synonym: 867160-71-2; OSI-906; OSI-906 (Linsitinib); Linsitinib(OSI-906); OSI906; OSI 906; OSI-906AA; ASP-7487; 3-[8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutan-1-ol; cis-3-(8-amino-1-(2-phenyl-7-quinolinyl)imidazo(1,5-a)pyrazin-3-yl)-1-methylcyclobutanol; cis-3-[8-Amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutanol; Cis-3-(8-Amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)-1-methylcyclobutan-1-ol; (1r,3r)-3-(8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)-1-methylcyclobutanol.; (1s,3s)-3-(8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)-1-methylcyclobutan-1-ol; (1s,3s)-3-(8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)-1-methylcyclobutanol; 3-[8-amino-1-(2-phenyl-7-quinolinyl)-3-imidazo[1,5-a]pyrazinyl]-1-methyl-1-cyclobutanol; cis-3-[8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutanol

CAS No.: 867160-71-2

Compound CID: 11640390

Formula: C₂₆H₂₃N₅

Formula Weight: 421.49

Specification

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: Linsitinib (OSI-906) is used in endocrinology and oncology research as a dual inhibitor of IGF-1R and the insulin receptor to study the circumvention of growth signaling redundancy in cancer therapy.