I-OMe-Tyrphostin AG 538

Cat. No.: OB0225WX-1513

Appearance: Solid

Purity: ≥96%

Identity: Confirmed by NMR, and LC-MS.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: I-OMe-Tyrphostin AG 538 is a specialized inhibitor of IGF-1R and an ATP-competitive inhibitor of PI5P4Kα (IC50: 1 µM) that selectively targets nutrient-deprived PANC1 cells by blocking IGF-1R signaling.

Synonym: I-OMe-AG 538; 1094048-77-7; (E)-2-(3,4-dihydroxybenzoyl)-3-(4-hydroxy-3-iodo-5-methoxyphenyl)prop-2-enenitrile; MLS002153417; SMR001230793; Alpha-Cyano-(3-methoxy-4-hydroxy-5-iodocinnamoyl)-(3',4'-dihydroxyphenyl)ketone; NCGC00016053-01; Lopac-T-7697; Lopac0_001251; I-OMe-Tyrphostin AG 538, solid; (E)-3-(4-hydroxy-3-iodo-5-methoxy-phenyl)-2-protocatechuoyl-acrylonitrile; (2E)-2-(3,4-dihydroxybenzoyl)-3-(4-hydroxy-3-iodo-5-methoxyphenyl)prop-2-enenitrile; (E)-2-[(3,4-dihydroxyphenyl)-oxomethyl]-3-(4-hydroxy-3-iodo-5-methoxyphenyl)-2-propenenitrile; (E)-2-[3,4-bis(oxidanyl)phenyl]carbonyl-3-(3-iodanyl-5-methoxy-4-oxidanyl-phenyl)prop-2-enenitrile

CAS No.: 1094048-77-7

Compound CID: 5353685

Formula: C₁₇H₁₂INO₅

Formula Weight: 437.19

Specification

Targets&IC50: PI5P4Kα: 1 µM

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: I-OMe-Tyrphostin AG 538 is utilized in cell biology research to study the inhibition of insulin-like growth factor-1 (IGF-1) receptor signaling and its subsequent effects on protein phosphorylation.