Merestinib

Cat. No.: OB0225WX-1809

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, HPLC, and LC-MS.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: Merestinib is a small molecule inhibitor of the c-Met proto-oncogene (Ki: 2 nM) that interferes with c-Met phosphorylation and downstream signal transduction pathways.

Synonym: LY2801653; 1206799-15-6; LY-2801653; N-(3-fluoro-4-((1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl)oxy)phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide; N-[3-fluoro-4-[1-methyl-6-(1H-pyrazol-4-yl)indazol-5-yl]oxyphenyl]-1-(4-fluorophenyl)-6-methyl-2-oxopyridine-3-carboxamide; Merestinib (LY2801653); N-[3-Fluoro-4-[[1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl]oxy]phenyl]-1-(4-fluorophenyl)-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarboxamide; 3-Pyridinecarboxamide, N-(3-fluoro-4-((1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl)oxy)phenyl)-1-(4-fluorophenyl)-1,2-dihydro-6-methyl-2-oxo-; N-(3-Fluoro-4-{[1-Methyl-6-(1h-Pyrazol-4-Yl)-1h-Indazol-5-Yl]oxy}phenyl)-1-(4-Fluorophenyl)-6-Methyl-2-Oxo-1,2-Dihydropyridine-3-Carboxamide; N-(3-Fluoro-4-(1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yloxy)phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide

CAS No.: 1206799-15-6

Compound CID: 44603533

Formula: C₃₀H₂₂F₂N₆O₃

Formula Weight: 552.53

Specification

Targets&IC50: MET: 2 nM(Ki)

Relative Density: 1.42 g/cm³

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: Merestinib is utilized in oncology research as a multi-kinase inhibitor to study the simultaneous targeting of MET, AXL, and MERTK pathways in metastatic cancer models.