Picropodophyllin (PPP)

Cat. No.: OB0225WX-2698

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, and HPLC.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: Picropodophyllin is a selective IGF-1R inhibitor (IC50: 1 nM) that does not cross-inhibit the insulin receptor (IR) or other related tyrosine kinases like EGFR and PDGFR.

Synonym: AXL1717; 477-47-4; Picropodophyllin; Picropodophyllotoxin; Cyclolignan PPP; Picro-podophyllin; AXL-1717; (-)PPP; IGF-1R Inhibitor, PPP; Podophyllotoxin picropodophyllin; (5R,5aR,8aS,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one; (5R,5aS,8aR,9R)-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one; Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R-(5-alpha,5a-alpha,8a-alpha,9-alpha))-; (5R,5aS,8aR,9R)-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one; AXL1717 (Picropodophyllotoxin); (5R,5aS,8aR,9R)-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro(3',4':6,7)naphtho(2,3-d)(1,3)dioxol-6(5aH)-one; MFCD01742647

CAS No.: 477-47-4

Compound CID: 72435

Formula: C₂₂H₂₂O₈

Formula Weight: 414.41

Specification

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: Picropodophyllin is applied in molecular pharmacology as a potent and selective IGF-1R inhibitor to investigate the blockage of insulin-like growth factor signaling without interfering with the insulin receptor.