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Methylnissolin
Cat. No.:
0225LY-1247
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
Methylnissolin is a natural extract from Astragalus membranaceus that inhibits PDGF-BB-induced cell proliferation (IC50: 10 uM) by blocking the ERK1/2 MAP kinase cascade.
Synonym:
3-Hydroxy-9,10-dimethoxyptercarpan; 73340-41-7; Astrapterocarpan; 3-Hydroxy-9,10-dimethoxyptercarpan; (6aR,11aR)-9,10-dimethoxy-6a,11a-dihydro-6H-benzofuro[3,2-c]chromen-3-ol; (6aR,11aR)-3-Hydroxy-9,10-dimethoxypterocarpan; (6aR,11aR)-9,10-dimethoxy-6a,11a-dihydro-6H-[1]benzofuro[3,2-c]chromen-3-ol
CAS No.:
73340-41-7
Compound CID:
14077830
Formula:
C17H16O5
Formula Weight:
300.31
Specification
Targets&IC50:
PDGFR: 10 μM (IC50)
Relative Density:
1.312 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Methylnissolin can be used in natural product research to explore its anti-inflammatory and potential protective effects on vascular endothelium.
Library Information
Target:
PDGFR; ERK
Receptor:
PDGFR; ERK
Pathways:
Tyrosine kinase/adaptors; MAPK; Angiogenesis
Plate Number:
AOCL-17
Plate Location:
a4
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
100 mg/mL; 332.99 mM
