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Pazopanib
Cat. No.:
0225LY-0517
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, HPLC, and LC-MS.
Size:
Add to basket
Product Overview
Description:
Pazopanib acts as an inhibitor of several protein tyrosine kinases, including FGFR1, c-Kit, PDGFRβ, and VEGFR1–3, with IC50 values ranging from 10 nM to 146 nM, contributing to its antitumor efficacy.
Synonym:
GW786034; 444731-52-6; 5-((4-((2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino)pyrimidin-2-yl)amino)-2-methylbenzenesulfonamide; 5-[[4-[(2,3-Dimethylindazol-6-yl)-methylamino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide
CAS No.:
444731-52-6
Compound CID:
10113978
Formula:
C21H23N7O2S
Formula Weight:
437.52
Specification
Targets&IC50:
VEGFR2: 30 nM; VEGFR3: 47 nM; VEGFR1: 10 nM; PDGFR: 84 nM; c-Kit: 74 nM
Relative Density:
1.40 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Pazopanib can be used in angiogenesis research to evaluate the simultaneous inhibition of VEGFR, PDGFR, and c-Kit receptors.
Library Information
Target:
FGFR; VEGFR; c-Kit; PDGFR
Receptor:
c-Kit; FGFR; PDGFR; VEGFR1; VEGFR2; VEGFR3
Pathways:
Tyrosine kinase/adaptors; Angiogenesis; Autophagy
Plate Number:
AOCL-7
Plate Location:
f10
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
25 mg/mL; 57.14 mM
Water Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
Ethanol Max Solubility:
<1 mg/mL
ALogP:
3.741
HBA_Count:
5
HBD_Count:
2
Rotatable Bond:
5
