Sitravatinib (MGCD516)

Cat. No.: OB0225WX-2765

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, and HPLC.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: Sitravatinib is a novel small molecule designed to inhibit a broad spectrum of receptor tyrosine kinases (RTKs), including c-Kit, PDGFR alpha/beta, c-Met, and Axl.

Synonym: MG-516; 1123837-84-2; MGCD516; MG-516; MGCD-516; Sitravatinib (MGCD516); MG-91516; 1-N'-[3-fluoro-4-[2-[5-[(2-methoxyethylamino)methyl]pyridin-2-yl]thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide; N-(3-fluoro-4-((2-(5-(((2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide; MGCD 516; 1,1-Cyclopropanedicarboxamide, N-(3-fluoro-4-((2-(5-(((2-methoxyethyl)amino)methyl)-2-pyridinyl)thieno(3,2-b)pyridin-7-yl)oxy)phenyl)-N'-(4-fluorophenyl)-; 1,1-Cyclopropanedicarboxamide, N-[3-fluoro-4-[[2-[5-[[(2-methoxyethyl)amino]methyl]-2-pyridinyl]thieno[3,2-b]pyridin-7-yl]oxy]phenyl]-N'-(4- fluorophenyl)-; N-(3-Fluoro-4-((2-(5-(((2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno(3,2-b)pyridin-7-yl)oxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

CAS No.: 1123837-84-2

Compound CID: 25212148

Formula: C₃₃H₂₉F₂N₅O₄S

Formula Weight: 629.68

Specification

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: Sitravatinib is utilized in advanced oncology research as a multi-targeted tyrosine kinase inhibitor to investigate the simultaneous inhibition of VEGFR, TAM, and Split family receptors in the tumor microenvironment.