Golvatinib (E7050)

Cat. No.: OB0225WX-2526

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, and HPLC.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: Golvatinib (E7050) is a dual-target kinase inhibitor that suppresses both c-Met and VEGFR-2 with potent IC50 values of 14 nM and 16 nM, respectively.

Synonym: Golvatinib; 928037-13-2; Golvatinib (E7050); E-7050; E7050; 1-N'-[2-fluoro-4-[2-[[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]amino]pyridin-4-yl]oxyphenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide; N-[2-Fluoro-4-[[2-[[[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl]amino]pyridin-4-yl]oxy]phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide; N'-[2-fluoro-4-[2-[[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]amino]pyridin-4-yl]oxyphenyl]-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide; N-(2-Fluoro-4-((2-(4-(4-methylpiperazin-1-yl)piperidine-1-carboxamido)pyridin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide; golvatinibum; N'-(2-fluoro-4-(2-((4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)amino)pyridin-4-yl)oxyphenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide; N'1-(2-fluoro-4-((2-((4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)amino)pyridin-4-yl)oxy)phenyl)-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide; N'1-{2-fluoro-4-[(2-{[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]amino}pyridin-4-yl)oxy]phenyl}-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide; N-(2-Fluoro-4-{[2-({[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}amino)pyridin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide; N-[2-Fluoro-4-[[2-[[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]amino]-4-pyridinyl]oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide; N-[2-Fluoro-4-[[2-[[[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl]amino]pyridin-4-yl]oxy]phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide; E-7050; E7050; MFCD22124462; 1,1-Cyclopropanedicarboxamide, N-(2-fluoro-4-((2-(((4-(4-methyl-1-piperazinyl)-1- piperidinyl)carbonyl)amino)-4-pyridinyl)oxy)phenyl)-N'-(4-fluorophenyl)-

CAS No.: 928037-13-2

Compound CID: 16118392

Formula: C₃₃H₃₇F₂N₇O₄

Formula Weight: 633.69

Specification

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: Golvatinib (E7050) is applied in cancer research as a dual c-Met and VEGFR2 inhibitor to investigate the simultaneous suppression of tumor growth factor signaling and angiogenesis.