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Salmon PMCH (DTMRCMVGRVYRPCWEV)
Cat. No.:
OB0526-WX80
Origin:
Synthetic
Conjugation:
Unconjugate
Species Reactivity:
Salmon
Size:
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Product Overview
Description:
Salmon PMCH (DTMRCMVGRVYRPCWEV) is a synthetic peptide corresponding to a region of salmon pro-melanin-concentrating hormone (PMCH). It is commonly used in comparative endocrinology, neuropeptide research, and receptor interaction studies. The peptide provides a useful tool for investigating conserved PMCH signaling pathways across species.
Sequence:
DTMRCMVGRVYRPCWEV
Molecular Weight:
2009.5 Da
Purity:
≥90% by HPLC
Applications:
Western blotting; ELISA; IHC; IF; Functional Assay; Cell Culture; Binding Assay
Specification
Storage:
Storage at -20°C.
Shipping Condition:
Shipped with ice packs.
Handling Notes:
During shipping, trace amounts of the blocking peptide may adhere to the interior surface of the vial cap. Before opening, it is highly recommended to briefly centrifuge the vial to bring all contents to the bottom.
Target Profile
Full Name:
Pro-Melanin Concentrating Hormone
Alternative Names:
Prepro-Melanin-Concentrating Hormone、Pro-Melanin-Concentrating Hormone、MCH、Prepro-MCH、Pro-MCH、PpMCH
Summary:
PMCH encodes a prepropeptide that is proteolytically processed into multiple neuropeptides, including melanin-concentrating hormone (MCH), neuropeptide-glutamic acid-isoleucine, and neuropeptide-glycine-glutamic acid. MCH is a 19-amino acid neuropeptide that stimulates hunger and is linked to regulation of energy homeostasis, reproductive function, and sleep. PMCH is expressed at high levels in brain and is associated with chemical synaptic transmission and neuropeptide signaling. The gene product is found in the extracellular region, nucleus, and synapse, fitting its role in signaling at neuronal connections. It participates in G protein-coupled receptor signaling pathway, negative regulation of synaptic transmission, dopaminergic, and regulation of feeding behavior. These activities place PMCH within broader signal transduction processes and also connect it to cell differentiation and spermatogenesis. Clinical significance for PMCH centers on its neuropeptide products and their effects on appetite and physiologic regulation. Melanin-concentrating hormone is reported to stimulate hunger and to be involved in energy homeostasis, reproductive function, and sleep. The gene has also been linked to pseudogenes on chromosome 5, and the proprotein structure supports generation of multiple bioactive products from a single precursor.
