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Rheb inhibitor NR1
Cat. No.:
0225LY-0577
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
Rheb inhibitor NR1 acts as a selective mTORC1 inhibitor that enhances S473pAKT phosphorylation while suppressing T389pS6K1 phosphorylation.
Synonym:
2216763-38-9; 4-Bromo-6-[(3,4-dichlorophenyl)sulfanyl]-1-{[4-(dimethylcarbamoyl)phenyl]methyl}-1H-indole-2-carboxylic acid; 4-Bromo-6-((3,4-dichlorophenyl)thio)-1-(4-; 4-Bromo-6-((3,4-dichlorophenyl)thio)-1-(4-(dimethylcarbamoyl)benzyl)-1H-indole-2-carboxylic acid; 1H-Indole-2-carboxylic acid, 4-bromo-6-((3,4-dichlorophenyl)thio)-1-((4-((dimethylamino)carbonyl)phenyl)methyl)-; 1H-Indole-2-carboxylic acid, 4-bromo-6-[(3,4-dichlorophenyl)thio]-1-[[4-[(dimethylamino)carbonyl]phenyl]methyl]-; 4-Bromo-6-((3,4-dichlorophenyl)thio)-1-((4-((dimethylamino)carbonyl)phenyl)methyl)-1H-indole-2-carboxylic acid
CAS No.:
2216763-38-9
Compound CID:
132281917
Formula:
C25H19BrCl2N2O3S
Formula Weight:
578.3
Specification
Relative Density:
1.53 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Rheb inhibitor NR1 can be used in signaling research to explore the regulation of the mTORC1 complex through Rheb GTPase antagonism.
Library Information
Target:
mTORC1
Receptor:
Serine/Threonine Protein Kinase
Pathways:
PI3K/Akt/mTOR signaling
Plate Number:
AOCL-8
Plate Location:
d11
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
50 mg/mL; 86.46 mM
