PCK1 Blocking Peptide (C-HVNWFRKDKEGK)

Cat. No.: OB0526-WX1

Origin: Synthetic

Conjugation: Unconjugate

Species Reactivity: Human; Mouse; Rat; Dog; Porcine; Cow

Size:

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Product Overview

Description: PCK1 Blocking Peptide (C-HVNWFRKDKEGK) is a synthetic peptide designed to specifically neutralize PCK1 antibodies in western blot and immunohistochemistry applications. It serves as an essential negative control to confirm antibody specificity and validate PCK1 expression during gluconeogenesis and lipid metabolism studies.

Sequence: C-HVNWFRKDKEGK

Molecular Weight: 1630.8 Da

Purity: ≥95%

Applications: Western blotting; ELISA; IHC; IF; Functional Assay; Cell Culture; Binding Assay

Specification

Storage: Storage at -20°C.

Shipping Condition: Shipped with ice packs.

Handling Notes: During shipping, trace amounts of the blocking peptide may adhere to the interior surface of the vial cap. Before opening, it is highly recommended to briefly centrifuge the vial to bring all contents to the bottom.

Target Profile

Full Name: Phosphoenolpyruvate carboxykinase 1

Alternative Names: Serine-protein kinase PCK1; PCK1; Phosphoenolpyruvate carboxykinase, cytosolic; PCKDC; PEPCK1; PEPCK-C; PEPCK1; PEPCKC; PEP carboxykinase; Cytosolic phosphoenolpyruvate carboxykinase 1; Phosphopyruvate carboxylase

Summary: PCK1 is a cytosolic enzyme that functions as a critical, rate-limiting checkpoint in the regulation of gluconeogenesis. In the presence of GTP, this protein catalyzes the conversion of oxaloacetate into phosphoenolpyruvate, accompanied by the release of carbon dioxide and GDP. Cellular levels and activity of this enzyme are dynamically modulated by metabolic regulators such as insulin, glucocorticoids, glucagon, cAMP, and dietary factors. Deficiencies in this functional protein lead to cytosolic phosphoenolpyruvate carboxykinase deficiency, distinguishing it from its mitochondrial isozyme counterpart.

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