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Monotropein
Cat. No.:
OB0225WX-2235
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR.
Size:
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Product Overview
Description:
Monotropein is an iridoid glycoside that inhibits the expression of iNOS, COX-2, and various inflammatory cytokines by inactivating the NF-kappaB signaling pathway.
Synonym:
Monotropeine; 5945-50-6; (1S,4aS,7R,7aS)-7-Hydroxy-7-(hydroxymethyl)-1-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1,4a,7,7a-tetrahydrocyclopenta[c]pyran-4-carboxylic acid; Cyclopenta(c)pyran-4-carboxylic acid, 1-(beta-D-glucopyranosyloxy)-1,4a,7,7a-tetrahydro-7-hydroxy-7-(hydroxymethyl)-, (1S-(1alpha,4aalpha,7beta,7aalpha))-; (1S,4aS,7R,7aS)-1-(beta-D-glucopyranosyloxy)-7-hydroxy-7-(hydroxymethyl)-1,4a,7,7a-tetrahydrocyclopenta(c)pyran-4-carboxylic acid; (1S,4aS,7R,7aS)-1-(beta-D-glucopyranosyloxy)-7-hydroxy-7-(hydroxymethyl)-1,4a,7,7a-tetrahydrocyclopenta[c]pyran-4-carboxylic acid; (1S,4aS,7R,7aS)-7-hydroxy-7-(hydroxymethyl)-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4a,7a-dihydro-1H-cyclopenta[c]pyran-4-carboxylic acid
CAS No.:
5945-50-6
Compound CID:
73466
Formula:
C16H22O11
Formula Weight:
390.34
Specification
Relative Density:
1.73 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Monotropein is utilized in inflammatory research as an iridoid glycoside to investigate its inhibitory effects on the NF-kappaB signaling pathway and its potential in protecting against bone loss and joint inflammation.
Library Information
Target:
NF-κB
Receptor:
NF-κB; iNOS; COX-2
Pathways:
Others
Plate Number:
AOCL-29
Plate Location:
e11
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
71 mg/mL; 181.9 mM
Solubility:
Soluble in pyridine, methanol, etc.
