MC4R Blocking Peptide (NSTHRGMHTSLH-C)

Cat. No.: OB0526-WX8

Origin: Synthetic

Conjugation: Unconjugate

Species Reactivity: Human

Size:

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Product Overview

Description: MC4R Blocking Peptide (NSTHRGMHTSLH-C) is an epitope-specific control peptide designed to pre-neutralize MC4R antibodies, effectively preventing targeted antibody binding during tissue staining. It is highly recommended as a validation tool for immunodetection of the MC4R in energy balance and genetic obesity models.

Sequence: NSTHRGMHTSLH-C

Molecular Weight: 1456.6 Da

Purity: ≥95%

Applications: Western blotting; ELISA; IHC; IF; Functional Assay; Cell Culture; Binding Assay

Specification

Storage: Storage at -20°C.

Shipping Condition: Shipped with ice packs.

Handling Notes: During shipping, trace amounts of the blocking peptide may adhere to the interior surface of the vial cap. Before opening, it is highly recommended to briefly centrifuge the vial to bring all contents to the bottom.

Target Profile

Full Name: Melanocortin receptor 4

Alternative Names: BMIQ20; MC4-R; MC4R

Summary: Melanocortin 4 receptor (MC4R) is a cell-surface G protein-coupled receptor that plays a central role in the neural regulation of appetite and energy balance. It responds to melanocortin peptides, including adrenocorticotropic hormone (ACTH) and melanocyte-stimulating hormone (MSH), to modulate feeding behavior and energy homeostasis. Loss-of-function variants in MC4R are a major cause of monogenic obesity and can result in autosomal dominant inheritance. The MC4R gene is intronless, consistent with its relatively simple genomic organization.

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