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LY2409881
Cat. No.:
OB0225WX-2701
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
Add to basket
Product Overview
Description:
LY2409881 acts as a high-potency IKK2 inhibitor with an IC50 of 30 nM, demonstrating more than 10-fold selectivity compared to IKK1 and other standard kinases.
Synonym:
946518-60-1; LY2409881 trihydrochloride; LY2409881 (trihydrochloride); 2-(5-chloro-2-((3-(4-methylpiperazin-1-yl)propyl)amino)pyrimidin-4-yl)-N-cyclopropylbenzo[b]thiophene-4-carboxamide trihydrochloride; s7697; 2-(5-chloro-2-(3-(4-methylpiperazin-1-yl)propylamino)pyrimidin-4-yl)-N-cyclopropylbenzo[b]thiophene-4-carboxamide trihydrochloride; 2-{5-chloro-2-[3-(4-methylpiperazin-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid cyclopropylamide tri-hydrochloride; LY-2409881 trihydrochloride; LY2409881 3HCl; 2-(5-chloro-2-{[3-(4-methylpiperazin-1-yl)propyl]amino}pyrimidin-4-yl)-N-cyclopropyl-1-benzothiophene-4-carboxamide trihydrochloride
CAS No.:
946518-60-1
Compound CID:
68856073
Formula:
C24H32Cl4N6OS
Formula Weight:
594.43
Specification
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
LY2409881 is utilized in oncology research as a selective inhibitor of IKK-epsilon to investigate the disruption of oncogenic signaling and the sensitization of malignant cells to therapeutic agents.
Library Information
Target:
IκB/IKK
Receptor:
IKK2
Pathways:
NF-κB
Plate Number:
L6700-09
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
20 mg/mL; 33.65 mM
ALogP:
5.147
HBA_Count:
3
HBD_Count:
2
Rotatable Bond:
8
