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LJH685
Cat. No.:
0225LY-0798
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
LJH685 serves as an effective pan-RSK inhibitor, targeting the RSK1, RSK2, and RSK3 isoforms with IC50 values of 6 nM, 5 nM, and 4 nM, respectively.
Synonym:
1627710-50-2; 2,6-Difluoro-4-[4-[4-(4-methylpiperazin-1-yl)phenyl]pyridin-3-yl]phenol; 2,6-Difluoro-4-{4-[4-(4-Methylpiperazin-1-Yl)phenyl]pyridin-3-Yl}phenol; CHEMBL3604793; 27CZQ807C1; Phenol, 2,6-difluoro-4-(4-(4-(4-methyl-1-piperazinyl)phenyl)-3-pyridinyl)-
CAS No.:
1627710-50-2
Compound CID:
73010393
Formula:
C22H21F2N3
Formula Weight:
381.42
Specification
Targets&IC50:
RSK1: 6 nM; RSK2: 5 nM; RSK3: 4 nM
Relative Density:
1.257 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
LJH685 can be used in intracellular signaling research to explore the selective inhibition of RSK kinases.
Library Information
Target:
S6 Kinase
Receptor:
RSK1; RSK2; RSK3
Pathways:
MAPK; Apoptosis; PI3K/Akt/mTOR signaling
Plate Number:
AOCL-11
Plate Location:
c7
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
29.4 mg/mL; 77.08 mM
Water Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
Ethanol Max Solubility:
16 mg/mL; 41.95 mM
