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Lipid 29
Cat. No.:
OB0626WX-3935
Appearance:
Liquid
Purity:
≥98%
Identity:
Confirmed by NMR, TLC, IR, and HPLC.
Size:
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Product Overview
Description:
Lipid 29 is a pH-responsive ionizable cationic amino lipid displaying a pKa of 6.91, designed as a core component for fabricating multicomponent delivery vehicles. The specific ionization profile of this amino lipid optimizes polyanionic cargo condensation at low pH, facilitating effective endosomal destabilization and intracellular processing to drive the robust systemic translation of encapsulated secretory transcripts in vivo.
Synonyms:
8-[[8-[(1-ethylnonyl)oxy]-8-oxooctyl][3-[[2-(methylamino)-3,4-dioxo-1-cyclobuten-1-yl]amino]propyl]amino]-octanoic acid, 1-octylnonyl ester; 2244716-55-8
CAS No.:
2244716-55-8
Compound CID:
135329651
Formula:
C52H97N3O6
Formula Weight:
860.4
Specification
Solubility in Ethanol:
25 mg/mL
Storage:
Storage at -20°C.
Applications:
Lipid 29 serves as an ionizable lipid for lipid nanoparticle formulation and nucleic acid delivery research. It supports comparative evaluation of lipid performance, formulation optimization, and structure–activity relationship studies in LNP development.