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Lipid 23
Cat. No.:
OB0626WX-3848
Appearance:
Liquid
Purity:
≥95%
Identity:
Confirmed by NMR, TLC, and HPLC.
Size:
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Product Overview
Description:
Lipid 23 is an ionizable cationic amino lipid boasting a defined pKa of 5.7, developed as a highly specialized matrix component for constructing multi-lipid delivery vehicles. The low pKa profile ensures a completely neutral surface charge at physiological pH while enabling rapid protonation within acidic compartments, directing the selective accumulation of encapsulated messenger RNA payloads into visceral hepatic tissues.
Synonyms:
8-((2-((4-(dimethylamino)butanoyl)oxy)ethyl)(10-oxo-10-(tridecan-7-yloxy)decyl)amino)octyl 2-hexyldecanoate
CAS No.:
3117189-61-1
Formula:
C55H108N2O6
Formula Weight:
893.5
Specification
Solubility in Other Solvents:
Methyl acetate: 25 mg/mL
Storage:
Storage at -20°C.
Applications:
Lipid 23 serves as an experimental lipid for lipid nanoparticle formulation and optimization. It supports studies of nucleic acid delivery, formulation screening, physicochemical characterization, and investigation of lipid composition effects on nanoparticle performance.