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KY19382
Cat. No.:
OB0225WX-1713
Appearance:
Solid
Purity:
≥98%
Identity:
Confirmed by NMR, and LC-MS.
Size:
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Product Overview
Description:
KY19382 acts as an orally active dual inhibitor of both GSK3β (IC50: 10 nM) and the CXXC5-DVL interaction (IC50: 19 nM), resulting in the potent activation of Wnt/β-catenin signaling.
Synonym:
2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382
CAS No.:
2226664-93-1
Compound CID:
148959784
Formula:
C17H11Cl2N3O2
Formula Weight:
360.19
Specification
Targets&IC50:
GSK-3β: 10 nM; CXXC5-DVL: 10 nM
Relative Density:
1.58 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
KY19382 is utilized in dermatological research as a dual-targeted molecule that inhibits CXXC5-Dvl interaction and GSK-3-beta to study the activation of the Wnt pathway for hair regrowth.
Library Information
Target:
Wnt/β-Catenin; GSK-3
Receptor:
CXXC5-DVL; GSK-3; GSK-3β; Wnt; β-Catenin
Pathways:
Cytoskeletal signaling; PI3K/Akt/mTOR signaling; Stem cells
Plate Number:
AOCL-22
Plate Location:
h8
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
5 mg/mL; 13.88 mM
