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JNK-IN-8
Cat. No.:
0225LY-0770
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
JNK-IN-8 is an irreversible inhibitor of JNK1, 2, and 4 (IC50s: 4.7, 18.7, and 1 nM) that demonstrates over 10-fold selectivity over Fms and MNK2.
Synonym:
1410880-22-6; 3-[[(E)-4-(dimethylamino)but-2-enoyl]amino]-N-[3-methyl-4-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide; (E)-3-(4-(dimethylamino)but-2-enamido)-N-(3-methyl-4-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide; Benzamide, 3-[[4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[3-methyl-4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-
CAS No.:
1410880-22-6
Compound CID:
57340686
Formula:
C29H29N7O2
Formula Weight:
507.59
Specification
Targets&IC50:
JNK1: 4.7 nM; JNK2: 18.7 nM; JNK: 1 nM
Relative Density:
1.283 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
JNK-IN-8 can be used in cell signaling research as a potent, covalent inhibitor to study the biological functions of the c-Jun N-terminal kinase (JNK) pathway.
Library Information
Target:
c-Kit; JNK
Receptor:
JNK1; JNK2; JNK3; Kit (V559D); Kit (V559D,T670I)
Pathways:
MAPK; Tyrosine kinase/adaptors
Plate Number:
AOCL-10
Plate Location:
h8
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
56 mg/mL; 110.33 mM
Water Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
Ethanol Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
