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iRGD peptide
Cat. No.:
OB0626WX-3688
Appearance:
Solid
Purity:
≥95%
Identity:
Confirmed by NMR and HPLC.
Size:
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Product Overview
Description:
iRGD peptide is a highly selective, tumor-homing peptide designed to surface-functionalize diverse nano-architectures and lipid nanoparticles. The integrated peptide sequence binds specific cell-surface integrins and neuropilins, directing delivery matrices away from visceral clearance organs and preferentially accumulating within targeted tumor tissue networks. Upon receptor binding, this targeting motif triggers deep tissue penetration and cell-mediated internalization pathways, working synergistically with encapsulated small-molecule degraders or pH-responsive polymer matrices to disrupt mitochondrial oxygen consumption, alter the microenvironment, and induce targeted cell death.
Synonyms:
cyclic (1→9)-disulfide L-cysteinyl-L-arginylglycyl-L-α-aspartyl-L-lysylglycyl-L-prolyl-L-α-aspartyl-L-cysteine; cyclic[Cys-Arg-Gly-Asp-Lys-Gly-Pro-Asp-Cys]; Internalizing Arginine-Glycine-Aspartic Acid Peptide; CEND-1; Internalized-arginylglycylaspartic acid cyclic peptide; CEND 1; LSTA 1; 1392278-76-0; c(CRGDKGPDC); iRGD; (6S,9S,15S,18R,23R,26S,29S)-18-amino-6-(4-aminobutyl)-9,26-bis(carboxymethyl)-15-[3-(diaminomethylideneamino)propyl]-2,5,8,11,14,17,25,28-octaoxo-20,21-dithia-1,4,7,10,13,16,24,27-octazabicyclo[27.3.0]dotriacontane-23-carboxylic acid; L-Cysteine, L-cysteinyl-L-arginylglycyl-L-alpha-aspartyl-L-lysylglycyl-L-prolyl-L-alpha-aspartyl-, cyclic (1-->9)-disulfide; iRGD-peptide; (3S,6R,11R,14S,20S,23S,31aS)-11-Amino-23-(4-aminobutyl)-14-(3-carbamimidamidopropyl)-3,20-bis(carboxymethyl)-1,4,12,15,18,21,24,27-octaoxooctacosahydro-1H-pyrrolo[2,1-j][1,2,5,8,11,14,17,20,23,26]dithiaoctaazacyclononacosine-6-carboxylic acid; (6S,9S,15S,18R,23R,26S,29S)-18-amino-6-(4-aminobutyl)-9,26-bis(carboxymethyl)-15-(3-guanidinopropyl)-2,5,8,11,14,17,25,28-octaoxo-20,21-dithia-1,4,7,10,13,16,24,27-octazabicyclo[27.3.0]dotriacontane-23-carboxylic acid
CAS No.:
1392278-76-0
Compound CID:
134611625
Formula:
C35H57N13O14S2
Formula Weight:
948
Specification
Solubility in DMSO:
≥10 mg/mL
Solubility in Other Solvents:
PBS: ≥10 mg/mL
Storage:
Storage at -20°C.
Applications:
iRGD peptide is utilized in chemical biology and delivery research as a targeting peptide component for investigating ligand-functionalized systems. It supports studies involving peptide-mediated recognition strategies, surface modification approaches, and evaluation of targeted delivery platform design.
