GSK583

Cat. No.: OB0225WX-2741

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, and HPLC.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: GSK583 functions as a high-potency RIP2 kinase inhibitor (IC50: 5 nM) that also suppresses the production of IL-6 and TNF-alpha with an IC50 of approximately 200 nM in explant models.

Synonym: 1346547-00-9; GSK 583; 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine; GSK'583; 6-(Tert-Butylsulfonyl)-N-(5-Fluoro-2h-Indazol-3-Yl)quinolin-4-Amine; N-(5-fluoro-1H-indazol-3-yl)-6-(2-methylpropane-2-sulfonyl)quinolin-4-amine; 6-tert-butylsulfonyl-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine; GSK-583; MFCD30343846; 6(tert-Butylsulfonyl)N(5-fluoro1Hindazol-3-yl)quinolin-4-amine; 6-(t-butylsulfonyl)-N-(5-fluoro-1h-indazol-3-yl)quinolin-4-amine; 6a?tert-Butylsulfonyl)a'Na?5-fluoroa?Ha'indazol-3-yl)quinolin-4-amine; 6GD

CAS No.: 1346547-00-9

Compound CID: 67469084

Formula: C₂₀H₁₉FN₄O₂S

Formula Weight: 398.45

Specification

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: GSK583 is utilized in inflammatory research as a potent and selective RIPK2 inhibitor to investigate the NOD1/2 signaling pathways and their contribution to autoimmune and autoinflammatory conditions.