GALR2 Blocking Peptide (C-RYPLHSRELRTPRN)

Cat. No.: OB0526-WX44

Origin: Synthetic

Conjugation: Unconjugate

Species Reactivity: Human; Mouse; Rat; Dog; Cow

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Product Overview

Description: GALR2 Blocking Peptide (C-RYPLHSRELRTPRN) is a sequence-defined synthetic peptide corresponding to a specific antigenic region of the GALR2 protein. Pre-incubation of antibodies with this peptide effectively blocks epitope-dependent binding and supports confirmation of signal specificity. It is recommended as a negative control for WB, IHC, and IF studies.

Sequence: C-RYPLHSRELRTPRN

Molecular Weight: 1911.2 Da

Purity: ≥95%

Applications: Western blotting; ELISA; IHC; IF; Functional Assay; Cell Culture; Binding Assay

Specification

Storage: Storage at -20°C.

Shipping Condition: Shipped with ice packs.

Handling Notes: During shipping, trace amounts of the blocking peptide may adhere to the interior surface of the vial cap. Before opening, it is highly recommended to briefly centrifuge the vial to bring all contents to the bottom.

Target Profile

Full Name: Galanin receptor type 2

Alternative Names: GALR2; GAL2-R; GALR-2; GALNR2; Galanin receptor 2

Summary: Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq, Jul 2008]

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