FTO Blocking Peptide (QQKPDCRPYWEKDD)

Cat. No.: OB0526-WX9

Origin: Synthetic

Conjugation: Unconjugate

Species Reactivity: Human; Mouse; Rat; Dog; Porcine

Size:

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Product Overview

Description: FTO Blocking Peptide (QQKPDCRPYWEKDD) is a synthetic peptide matching a specific sequence of the FTO protein. Pre-incubating FTO antibodies with this blocking peptide allows researchers to confidently subtract non-specific background and establish assay baseline controls in RNA methylation and metabolic homeostasis studies.

Sequence: QQKPDCRPYWEKDD

Molecular Weight: 1811.9 Da

Purity: ≥95%

Applications: Western blotting; ELISA; IHC; IF; Functional Assay; Cell Culture; Binding Assay

Specification

Storage: Storage at -20°C.

Shipping Condition: Shipped with ice packs.

Handling Notes: During shipping, trace amounts of the blocking peptide may adhere to the interior surface of the vial cap. Before opening, it is highly recommended to briefly centrifuge the vial to bring all contents to the bottom.

Target Profile

Full Name: Alpha-ketoglutarate-dependent dioxygenase FTO

Alternative Names: FTO; GDFD; IFEX9; ALKBH9; BMIQ14; Fat mass and obesity-associated protein; U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; KIAA1752; mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; (m6A(m)-demethylase FTO

Summary: Alpha-ketoglutarate-dependent dioxygenase FTO is a nuclear enzyme belonging to the AlkB-related family of non-heme iron- and 2-oxoglutarate-dependent oxygenases. Members of this enzyme family can catalyze oxidative demethylation reactions involving modified nucleic acids. Research in humans and animal models has linked FTO to nervous system and cardiovascular functions, as well as body mass index (BMI), obesity susceptibility, and type 2 diabetes.

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