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F-1
Cat. No.:
0225LY-0787
Appearance:
Solid
Purity:
≥97%
Identity:
Confirmed by NMR, and LC-MS.
Size:
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Product Overview
Description:
F-1 is a potent dual inhibitor of ROS1 and ALK (IC50s: 2.3 and 2.1 nM for wild-type versions) that suppresses downstream signaling and phospho-ALK levels.
Synonym:
2244775-31-1
CAS No.:
2244775-31-1
Formula:
C22H27ClN8O3S
Formula Weight:
519.02
Specification
Targets&IC50:
ALK (L1196M): 1.3 nM; ALK (G1202R): 3.9 nM; ROS1 (WT): 2.3 nM; ALK (WT): 2.1 nM
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
F-1 can be used in chemical biology research to investigate the structure-activity relationship of novel kinase-targeting molecules.
Library Information
Target:
ALK
Receptor:
ALK
Pathways:
Immunology/Inflammation; Angiogenesis; Tyrosine kinase/adaptors
Plate Number:
AOCL-11
Plate Location:
b6
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
100 mg/mL; 192.67 mM
