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2,5-dimethyl Celecoxib
Cat. No.:
0225LY-1140
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by LC-MS.
Size:
Add to basket
Product Overview
Description:
2,5-dimethyl Celecoxib is a derivative of celecoxib that targets microsomal prostaglandin E synthase-1 (mPGES-1), a vital enzyme in the inflammatory PGE2 pathway.
Synonym:
457639-26-8; 2,5-Dimethyl Celecoxib; 2,5-dimethylcelecoxib; 2,5-dimethyl-celecoxib; 4-(5-(2,5-Dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide; Dimethyl celecoxib; 2,5-DimethylCelecoxib-d4; 4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide; 4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide; 4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1h-pyrazol-1-yl]benzenesulfonamide; Benzenesulfonamide, 4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-; 4-[5-(2,5-Dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
CAS No.:
457639-26-8
Compound CID:
11545682
Formula:
C18H16F3N3O2S
Formula Weight:
395.4
Specification
Relative Density:
1.40 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
2,5-dimethyl Celecoxib can be used in cell signaling research to study COX-2-independent pathways involved in apoptosis and anti-proliferation.
Library Information
Target:
Wnt/beta-catenin; Prostaglandin receptor
Receptor:
PGE2; Wnt/β-Catenin
Pathways:
Immunology/Inflammation; Apoptosis; GPCR/G protein signaling; Cytoskeletal signaling; Stem cell regulation
Plate Number:
AOCL-15
Plate Location:
f6
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
60 mg/mL; 151.75 mM
Ethanol Max Solubility:
3 mg/mL; 7.59 mM
Special Max Solubility:
DMF: 5 mg/mL (12.65 mM); DMSO:PBS (pH 7.2) (1:3): 0.25 mg/mL (0.63 mM)
