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(E)-Cardamonin
Cat. No.:
OB0225WX-2567
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
Add to basket
Product Overview
Description:
(E)-Cardamonin is a naturally occurring chalcone that functions as a novel TRPA1 antagonist (IC50: 454 nM) and a potent inhibitor of NF-kappaB signaling.
Synonym:
Alpinetin chalcone; Cardamomin; 19309-14-9; Dihydroxymethoxychalcone; Alpinetin chalcone; (E)-Cardamonin; (E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one; 2',4'-dihydroxy-6'-methoxychalcone; 1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one; 2-Propen-1-one, 1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenyl-, (2E)-; (E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one; 2-Propen-1-one, 1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenyl-; (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one; Cardamomin; Alpinetin chalcone; (E)-Cardamomin; (E)-Alpinetin chalcone; Cardamonin ,(S); 2'4'-Dihydroxy-6'-methoxy-chalcone; MFCD00238554
CAS No.:
19309-14-9
Compound CID:
641785
Formula:
C16H14O4
Formula Weight:
270.28
Specification
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
(E)-Cardamonin is employed in signal transduction research as a natural chalcone to investigate the suppression of the Wnt/beta-catenin and NF-kappaB pathways in various cancer and inflammatory models.
Library Information
Target:
NF-κB; TRP channel
Receptor:
NF-κB; TRP channel
Pathways:
NF-κB
Plate Number:
L6700-05
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
54 mg/mL; 199.79 mM
ALogP:
3.201
HBA_Count:
2
HBD_Count:
2
Rotatable Bond:
4
